OBJECTIVE： To compare the similarity of dissolution curves of Sertraline hydrochloride tablets from 12 manufacturers， and to evaluate the maturity and stability of technology. METHODS： The dissolution curves of Sertraline hydrochloride tablets from original manufacturer were investigated by using water， 0.1 mol/L hydrochloric acid， acetic acid-natrium aceticum buffer solution （pH 4.5） and phosphate buffer solution （pH 6.8） as medium respectively. The phosphate buffer solution （pH 6.8） 900 ml was selected to determine the uniformity and dissolution curves of Sertraline hydrochloride tablets from different manufacturers because it was superior to other medium in identification capacity. The similarity of dissolution curves were evaluated by f2 factor method. RESULTS： The uniformity results of samples from 12 manufacturers were acceptable， all RSDs of each point dissolution were less than 10％ （n＝6）； among 11 imitation manufacturers investigated， only one f2 value was more than 50， which was 9.1％ of the total. CONCLUSIONS： The stability of Sertraline hydrochloride tablets from 12 manufacturers were quite well， whereas， the quality of drugs from imitation manufacturers was greatly different from that of original drugs. It is suggested to intensively study the technology， formula， raw material and excipients source so as to improve drug quality.