OBJECTIVE： To establish a method for the residual determination of ethanol and acetone in Nimodipine sustained-release tablet. METHODS： Headspace GC was on the column of capillary column with fixative solution of 6％ cyanopropyl phenyl-94％ dimethyl polysiloxane （DB-624） by temperature programming， injector temperature was 230 ℃， detector was a flame ionization detector， detector temperature was 250 ℃， carrier gas was nitrogen gas， flow rate was 2.0 ml/min， split ratio was 5 ∶ 1， equilibrium temperature was 90 ℃， equilibrium time was 20 min， and volume of sample was 1.0 ml. RESULTS： The linear range was 1.25-500.0 μg/ml for ethanol （r＝0.999 9） and 0.50-202.0 μg/ml for acetone （r＝0.999 2）； limits of quantitative were 5.01， 2.02 μg/ml， limits of detection were 1.67， 0.67 μg/ml， respectively； RSDs of precision， stability and reproducibility tests were lower than 3.0％； recoveries were 96.81％-102.00％（RSD＝1.89％，n＝9），96.64％-102.31％（RSD＝1.82％，n＝9）， respectively. CONCLUSIONS： The method is simple， rapid， accurate， and can be used for simultaneous residual determination of ethanol and acetone in Nimodipine sustained-release tablet.