OBJECTIVE： To improve the vaccine management system in China and the role of licensed pharmacist participating in vaccine management， circulation and delivery. METHODS： The current situation， related supporting measures， and social benefits of licensed pharmacist participating in vaccine management were introduced to provide basis for the vaccine management for Chinese licensed pharmacists. RESULTS & CONCLUSIONS： In the beginning， American licensed pharmacists only educated physicians and the public， then developed to deliver vaccines in pharmacies supervised by practicing physicians， and participated in administration of vaccines both for adults and children， finally evolved to be part of the ADR monitoring system， etc. The way to participate vaccine management included receiving vaccination training， cardiopulmonary resuscitation training， vaccine continuing education and licensed pharmacist authorization； it has been participated in the vast majority of vaccine management currently. In order to make sure the professionalism， security and enthusiasm of licensed pharmacist in vaccine management， there were supporting measures established by Pharmacy Governing Council in America， including strengthening professional training， saving vaccinations， ADR monitoring records， developing responsibilities insurance and Medicare payment system. The above measures have strengthened patients’ willingness to take vaccine， improved the social acceptance of pharmacists and saved costs. The Chinese licensed pharmacists have not play their proper role， it is suggested to progressively realize licensed pharmacist participating in vaccine management to play the role of licensed pharmacists in vaccine management， circulation and delivery in aspects of constructing vaccine regulatory system of “dredging instead of blocking”， clearing positioning of pharmacy and improving the supporting measures of licensed pharmacist participating in vaccine management.