OBJECTIVE： To investigate therapeutic efficacy and safety of Salviae miltiorrhizae and ligustrazine hydrochloride injection in the treatment of vertebro-basilar artery insufficiency（VBI） after cerebral infraction. METHODS： 128 patients with VBI after cerebral infraction were divided into observation group and control group according to random number table，with 64 cases in each group. Both group received general treatment. Control group was additionally given Shuxuetong injection 6 ml added into 0.9％ Sodium chloride injection 250 ml，ivgtt，qd. Observation group was additionally given Salviae miltiorrhizae and ligustrazine hydrochloride injection 10 ml into 0.9％ Sodium chloride injection 250 ml，ivgtt，qd. Both groups received treatment for consecutive 2 weeks. Clinical efficacies of 2 groups were observed as well as blood lipid，vertebro-basilar artery blood velocity and blood viscosity before and after treatment. The occurrence of ADR was compared between 2 groups. RESULTS： The total effective rate of observation group was 95.31％，which was significantly higher than 79.69％ of control group，with statistical significance（P＜0.05）. Before treatment，there was no statistical significance in blood lipid，vertebro-basilar artery blood velocity and blood viscosity between 2 groups（P＞0.05）. After treatment， above indexes of 2 groups were improved significantly，and blood lipid and vertebro-basilar artery blood velocity of observation group were significantly better than control group，with statistical significance（P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Salviae miltiorrhizae and ligustrazine hydrochloride injection shows significant therapeutic efficacy for VBI after cerebral infraction，can significantly improve blood lipid，vertebro-basilar artery blood velocity and blood viscosity with good safety.