OBJECTIVE： To guide rational use of Heamocoagulase agkistrodon for injection， and to provide reference for pharmaceutical care. METHODS： Treatment methods and outcome of 9 cases of allergic shock induced by Heamocoagulase agkistrodon for injection were retrieved from CNKI and VIP database during 2009-2015， and then analyzed statistically， based on one case of allergic shock induced by Heamocoagulase agkistrodon for injection in the Affiliated Hospital of Zhunyi Medical College. RESULTS： 10 pationts with allergic shock induced by Heamocoagulase agkistrodon for injection mainly used the drug for hemostasis before and after surgery， heavy menstrual bleeding， etc.， with dose of 1 or 2 U. Route of administration included intravenous injection and intravenous dripping. Allergic shock often occurred within 30 min after medication. CONCLUSIONS： The use of Heamocoagulase agkistrodon for injection in some patients belongs to off-label drug use， and route of administration is different from that stated in package inserts. Allergic shock induced by Heamocoagulase agkistrodon for injection occurs rapidly； the drug should be used strictly according to package inserts and authoritative literatures； emergency plan should be developed before medication in order to guarantee the safety of drug use.