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ZHANG Ying; KE Zhenghua

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- China Pharmacy Vol. 27, Issue 33, (2016)
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ZHANG Ying, KE Zhenghua. [J]. China Pharmacy 27(33).(2016)
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ZHANG Ying, KE Zhenghua. [J]. China Pharmacy 27(33).(2016) DOI：

摘要

目的：系统评价血必净注射液对重症急性胰腺炎（SAP）患者炎症因子的影响，为临床提供循证参考。方法：计算机检索PubMed、中国期刊全文数据库、中国生物医学文献数据库、中文科技期刊数据库和万方数据库，收集血必净注射液对SAP患者炎症因子影响的随机对照试验（RCT），提取资料和评价纳入研究的偏倚风险后，采用Rev Man 5.2 统计软件进行Meta 分析。结果：共纳入10项RCT，合计811例患者。Meta 分析结果显示，血必净注射液能显著降低SAP患者白细胞介素（IL）-1水平[SMD＝1.22，95％CI（0.64，1.79），P＜0.001]、IL-6水平[SMD＝1.86，95％CI（1.46，2.27），P＜0.001]、IL-8水平[SMD＝2.16，95％CI（1.45，2.88），P＜0.001]、肿瘤坏死因子水平[SMD＝2.16，95％CI（1.56，2.76），P＜0.001]、C反应蛋白水平[SMD＝1.63，95％CI（0.56，2.70），P＜0.001]和内毒素水平[SMD＝2.39，95％CI（1.33，3.45），P＜0.001]，还能显著提高SAP患者IL-10水平[SMD＝－2.75，95％CI（－3.84，－1.67），P＜0.001]，差异均有统计学意义。结论：在常规治疗的基础上，血必净注射液可以显著改善SAP患者各种炎症因子水平。

Abstract

OBJECTIVE： To systematically review the effect of Xuebijing injection on inflammatory mediators in patients with severe acute pancreatitis （SAP）， and provide evidence-based reference for clinic. METHODS： Retreived from PubMed、CJFD， CBM， VIP and Wanfang Database， randomized controlled trials （RCT） about the effect of Xuebijing injection on inflammatory mediators in patients with SAP were collected. Meta-analysis was performed by using Rev Man 5.2 software after data extraction and bias risk evaluation. RESULTS： Totally 10 RCTs， involving 811 patients. Results of Met-analysis showed， Xuebijing injection can significantly reduce IL-1[SMD＝1.22，95％CI（0.64，1.79），P＜0.001]，IL-6[SMD＝1.86，95％CI（1.46，2.27），P＜0.001]，IL-8 [SMD＝2.16，95％CI（1.45，2.88），P＜0.001]，TNF-α[SMD＝2.16，95％CI（1.56，2.76），P＜0.001]，C-reactive protein [SMD＝1.63， 95％CI（0.56，2.70），P＜0.001] and endotoxin [SMD＝2.39，95％CI（1.33，3.45），P＜0.001]， and it also can significantly improve IL-10[SMD＝－2.75，95％CI（－3.84，－1.67），P＜0.001]， with statistical significance. CONCLUSIONS： Based on conventional trecotment，Xuebijing injection can significantly improve inflammatory mediators in patients with SAP.

关键词

血必净注射液重症急性胰腺炎白细胞介素肿瘤坏死因子C反应蛋白内毒素Meta分析

Keywords

Xuebijing injectionsevere acute pancreatitisInterleukinTumor necrosis factorC-reactive proteinEndotoxinMeta-analysis

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