OBJECTIVE： To provide reference for rational utilization of antibiotics for special use. METHODS： Medical orders of antibiotics for special use in clinical departments of our hospital during 2013 to 2015 were selected from hospital information system. The consumption sum and its ratio， DDDs， DDC， DUI and the utilization of antibiotics for special use in clinical departments were calculated and analyzed. RESULTS： The consumption sum and its ratio of antibiotics for special use in our hospital during 2013 to 2015 both reduced year by year， decreasing from 21 872 200 yuan （48.00％） to 20 877 700 yuan （39.41％）. The consumption sum ratio of carbapenems， cephalosporins and anti-deep fungal drugs showed descending tendency. The consumption sum ratio of anti-MRSA antibiotics changed slightly. DDDs of Meropenem for injection always took up the first place in recent 3 years， but the values were decreasing.  DUI of Imipenem and cilastain sodium for injection was far less than 1， while those of Panipenem and betamipron for injection， Cefepime sodium for injection and Caspofungin acetate for injection （70 mg/injection） were far more than 1. The types of drug with DUI ranged 0.9-1.1 increased year by year， increasing from 3 types in 2013 （18.75％） to 10 types in 2015 （62.50％）. Within 3 years， the utilization ratio of antibiotics for special use always took up the first place in ICU （86.64％-87.78％）. CONCLUSIONS： The consumption sum and its ratio of antibiotics for special use in our hospital during 2013 to 2015 decreased year by year， and the utilization of antibiotics for special use become increasingly rational. But， there still are some problems， such as inadequate dose of Imipenem and cilastain sodium for injection， overdose of Panipenem and betamipron for injection， Cefepime sodium for injection and Caspofungin acetate for injection （70 mg/injection）.