OBJECTIVE： To provide reference for improving the breast cancer patients’medication compliance. METHODS： 280 inpatients with advanced breast cancer who had received endocrine therapy in a hospital ward of chemotherapy of breast from Sept. to Nov. 2015 were selected， questionnaires was combined with on-site interview to investigate and analyze the medication compliance， influential factors and adverse reactions induced by endocrine drugs. RESULTS： Among the 280 patients， 161 （57.5％） showed good medication compliance， 64 （22.9％） were general and 55 （19.6％） were poor； its medication compliance were mainly affected by “wrong understanding on disease control （27.2％）”“adverse drug reactions （22.4％）”“forgetting taking medicines （21.1％）”； the common adverse reactions of endocrine therapy included hot flashes， mood disorders and joint pain. CONCLUSIONS： Clinical pharmacists， especially the specialists should give full play to their own professional advantage， strengthen patient medication education， actively participate ward round and follow-up， improve breast cancer patients’compliance on endocrine therapy.