OBJECTIVE： To provide reference for rational drug use. METHODS： 107 patients with drug-induced liver injury （DILI） admitted to liver disease department of our hospital during Jan. 2011 to Dec. 2015 were divided into TCM group and chemical medicine group according to the type of medicine. DILI clinical characteristics， prognosis， medicine types of DILI were compared and analyzed between 2 groups. RESULTS： 47 cases of DILI were induced by TCM， which mainly were health care and body beauty medicines （19.1％）， rheumatism and arthritis medicines （14.9％） and dermatological medicines （10.6％）. 60 cases of DILI were induced by chemical medicine， which mainly were antineoplastics （21.7％）， antimicrobial （20.0％） and antituberculotics （11.7％）. Gender， average age， the time from primary medication to disease attack and clinical classification were no significant difference between 2 groups（P＞0.05）. The clinical manifestations of the 2 groups were similar， except that fatigue was more common in the TCM group， with statistical significance（P＜0.05）. The liver function indicators of TCM group as ALT， AST， TBIL and ALP were higher than those of chemical medicine group， while ALT and TBIL were significantly different between 2 groups（P＜0.05）. The liver injuries were more serious in the TCM group than in chemical medicine group， with statistical significance （P＜0.05）. After treatment， the prognosis and the prognosis of liver function indicator in 2 groups were not statistically significant（P＞0.05）. CONCLUSIONS： Doctors and pharmacists should cooperate to master medication indication strictly， develop ADR monitoring and conduct blood concentration monitoring of high-risk DILI medicines， especially the hepatotoxicity of TCM so as to reduce the occurrence of DILI and guarantee the safety of clinical drug use.