OBJECTIVE： To provide new strategies and ideas to breakthrough dilemma on new drug research and obtain good drug. METHODS： Source and dilemma on drug discovery and development were analyzed， and new strategies were provided to solve it， and the role of clinical pharmacy work in the drug discovery was analyzed. ?RESULTS： Compared with its traditional strategies， clinical verification and big strategies in drug discovery had advantages in reducing risk， cutting input and shortening the period of new drug research and development. Clinical pharmacy work will provide strong support for the new strategy of drug discovery. CONCLUSIONS： Drug discovery should transform to clinic-based patterns， and it requires the tightly bonding between the pattern and clinical pharmacy work.