OBJECTIVE： To investigate the therapeutic efficacy and safety of mycophenolate mofetil combined with glucocorticoid in the treatment of refractory idiopathic thrombocytopenic purpura （ITP）. METHODS： 134 cases of refractory ITP were randomly divided into observation group and control group， with 67 cases in each group. Control group was given Prednison acetate tablet orally， 0.5 mg/kg each day， morning and evening. Observation group was additionally given Mycophenolate mofetil dispersible tablet， 1 g/time， bid. A treatment course lasted for 3 weeks， and both groups received 3-5 courses of treatment. Clinical efficacy of 2 groups were compared as well as the change of PLT before and after treatment， satisfaction degree of treatment and adverse event. RESULTS： The total effective rate of observation group （91.04％） was significantly higher than that of control group （74.63％）， with statistical significance （P＜0.05）； PLT of observation group was significantly greater than that of control group 7， 14 and 21 d after treatment， with statistical significance （P＜0.05）； total satisfactory degree of observation group was significantly higher than that of control group （89.55％ vs. 80.60％）， and the incidence of adverse event was significantly lower than control group （2.99％ vs. 10.44％）， with statistical significance （P＜0.05）. CONCLUSIONS： Mycophenolate mofetil combined with glucocorticoid can improve clinical efficacy， PLT and satisfactory degree significantly in the treatment of refractory ITP with good safety.