OBJECTIVE： To systematically review the efficacy of Duhuo jisheng decoction combined with chemical medicines in the treatment of ankylosing spondylitis （AS）， and to provide reference for clinical treatment. METHODS： Retrieved from CBM， CJFD， VIP， Wanfang Database，PubMed and EMBase， randomized controlled trials （RCT） about Duhuo jisheng decoction combined with chemical medicines （test group） versus chemical medicines alone （control group） in the treatment of AS were collected， Meta-analysis was performed by using Rev Man 5.3 software after data extraction and quality evaluation. RESULTS： Totally 6 RCTs were included， involving 382 patients. Results of Meta-analysis showed， the total effective rate [RR＝1.35，95％CI（1.20，1.52）， P＜0.001]， improvement rate of TCM symptoms [RR＝1.31，95％CI（1.09，1.57），P＝0.004） in test group were significantly higher than control group，and CRP level was lower than contxol group[MD＝－6.18， 95％CI（－8.49，－3.87），P＜0.001]，the difference was statistically significant. CONCLUSIONS： Duhuo jisheng decoction combined with chemical medicines shows better efficacy than chemical medicines alone， it can improve the TCM symptoms and decrease the CRP level.