OBJECTIVE： To provide reference for rational prophylactic application of antibiotics in perioperative period of permanent cardiac pacemaker implantation. METHODS： 600 cases performed permanent cardiac pacemaker implantation in 2010 （before rectification），2012 （during rectification） and 2014 （after rectification） were randomly sampled from our hospital， and divided into control group， intervention group one and intervention group two. The prophylactic application of antibiotics was investigated and analyzed in 3 groups. RESULTS： For control group， intervention group one and intervention group two， the rates of rational type selection of antibiotics for prophylactic use were 7.25％， 31.00％ and 91.96％， respectively. The rates of rational medication timing of antibiotics for prophylactic use were 0， 100％ and 100％； average duration of prophylactic use decreased from （3.6±1.2） d before intervention to （1.1±0.5） d and （1.0±0.2） d. There was no statistical significance in the incidence of postoperative infection （P＞0.05）. Compared with control group， average drug cost， antibiotics cost and drug ratio decreased significantly in intervention group， with statistical significane （P＜0.05）. CONCLUSIONS： Antibiotics special rectification is effective and improve the rational application of antibiotics in our hospital.