OBJECTIVE： To observe the effects of bisoprolol combined with conventional triple therapy on the efficacy and related indexes of patients with rheumatic heart valvular disease （RVD） combined chronic heart failure. METHODS： 110 patients with RVD combined with chronic heart failure were randomly divided into observation group （55 cases） and control group （55 cases）. All patients were treated with oxygen inhalation， anti-infection， correcting electrolyte imbalance， controlling arrhythmia， and giving digitalis drugs and diuretic drugs （it can be disabled after edema symptom being controlled）； based on it， control group was given Enalapril tablet with initial dose of 2.5 mg， once to twice a day， then adjusted to 10-20 mg after 1 week， twice a day+20 mg Spironolactone tablet， once a day+10 mg Propranolol tablet， once a day. Observation group was additionally given Bisoprolol fumarate tablet initial dose of 1.25 mg， once a day， and then increased to 10 mg based on condition improved and tolerability after a meal， once a day. They were treated for 12 weeks. Clinical efficacy， and LVEF， LVEDD， LVESD， SBP， DBP， HR before and after treatment and incidence of adverse reactions in 2 groups were observed. RESULTS： The total effective rate in observation group was significantly higher than control group， the difference was statistically significant （P＜0.05）. Before treatment， there were no significant differences in the LVEF， LVEDD， LVESD， SBP， DBP and HR between 2 groups （P＞0.05）. After treatment， LVEF in 2 groups were significantly higher than before， and observation group was higher than control group， LVEDD， LVESD， SBP， DBP and HR were significantly lower than before， and observation group was lower than control group， the differences were statistically significant（P＜0.05）. And there was no significant difference in the incidence of adverse reactions（P＞0.05）. CONCLUSIONS： Based on conventional treatment， bisoprolol combined with conventional triple therapy shows good efficacy in the treatment of RVD combined chronic heart failure， it can improve cardiac function， with good safety.