OBJECTIVE： To observe the efficacy and safety of edaravone combined with nimodipine in the treatment of acute large area cerebral infarction. METHODS： 78 patients with acute large area cerebral infarction were randomly divided into control group （38 cases） and observation group （40 cases）. Control group received aspirin platelet aggregation， reduced intracranial pressure， maintained water and electrolyte balance， decreased cerebral edema， Xuesetong for injection， Ginkgobiloba injection， lipid and blood pressurelowering， maintained blood sugar and other conventional treatment； observation group additionally received 30 mg Edaravone injection， adding into 100 ml 0.9％ Sodium chloride injection by intravenous infusion （drip completed within 30 min）， twice a day+12 mg Nimodipine injection， adding into 500 ml 0.9％ Sodium chloride injection by intravenous infusion， once a day， with drip rate of 0.5-1 mg/h， for continuous 10 d， then received 40 mg Nimodipine tablet， orally， 3 times a day. The treatment course for both groups was 15 d. Clinical efficacy， blood oxygen saturation （SpO2）， hemoglobin （Hb）， total hemoglobin （HbT）， reduced hemoglobin （MHb） before and after treatment， and the incidence of adverse reactions in 2 groups were observed. RESULTS： The total effective rate in observation group was significantly higher than control group， the incidence of adverse reactions was significantly lower tahn control group， the differences were statistically significant （P＜0.05）. Before treatment， there were no significant differences in SpO2， Hb， HbT and MHb in 2 groups （P＞0.05）. After treatment， the SpO2， HbT and MHb were significantly higher than before， and observation group was higher than control group， the differences were statistically significant （P＜0.05）； Hb was significantly lower than before， the differences were statistically significant （P＜0.05）， but there was no significant difference between 2 groups （P＞0.05）. CONCLUSIONS： Based on the conventional treatment， edaravone combined with nimodipine shows significant efficacy in the treatment of acute large area cerebral infarction， it can effectively recovery neurological function damage and protect the brain tissue， which can reduce the incidence of adverse.