OBJECTIVE： To evaluate the role of PDCA cycle management on standardizing clinical use of atomization inhalation drug. METHODS： Using a retrospective method， 300 medical records of atomization inhalation drug use were collected from our hospital during Jan.-Dec. in 2013 （non-intervention group）， 200 medical records collected during Apr.-Jun. in 2014 （one cycle intervention group）， and 180 medical records collected during Oct.-Dec. in 2014 （two rounds of cycle intervention group）. The use of atomization inhalation drugs was compared before and after the application of PDCA cycle management. Before and after two cycle intervention， 4 types of medical staff were investigated on cognition of the related knowledge of atomization inhalation drugs， as physicians， pharmacists， nurses and mechanic. RESULTS： After two rounds of PDCA cycle management and intervention， the proportion of unsuitable route of administration of antibiotics， long acting glucocorticoid， non-atomization inhalation dosage form of resolving phlegm drugs， protease decreased from 54.0％， 62.0％， 59.7％， 44.7％ before intervention to 0.6％， 1.1％， 15.0％， 1.1％ after intervention； those phenomena had not been found， such as unsuitable route of administration of TCM injection and non-atomization dosage form of theophyllines， unsuitable atomization frequence， unsuitable indication， drug mixture for preventing and controlling symptom， etc. The proportion of medical staffs being familiar with medical device， drug classification， drug selection for prerention and treatment and the proportion of hospital drug stock to 93.4％， 86.7％， 92.4％， 96.2％ after intervention from 38.0％， 79.0％， 49.0％， 39.5％ before intervention. CONCLUSIONS： The application of PDCA cycle management can effectively regulate the use of atomization inhalation drugs in our hospital； the method can be promoted and applied.