OBJECTIVE： To observe therapeutic efficacy and safety of Danshen chuanxiongqin injection combined with flunarizine hydrochloride in the benign prevention and treatment of paroxysmal positional vertigo （BPPV） and lower extremity deep venous thrombosis （DVT） in post-operative long-term bedridden patients with lower limb fractures. METHODS： 300 post-operative long-term bedridden patients with lower limb fractures were selected and randomly divided into observation group and control group， with 150 cases in each group. Control group was given Flunarizine hydrochloride capsules orally 10 mg， qd； observation group was additionally given Danshen chuanxiongqin injection 10 ml+5％ Glucose injection 250 ml， ivgtt， qd. The incidence of BPPV and DVT were observed in 2 groups after intervention， and the circumference of lower limb， blood coagulation indexes， blood rheology indexes and inflammatory factor were observed before and after intervention， and the incidence of ADR was compared. RESULTS： The incidence of BPPV and DVT in observation group were 18.0％ and 16.7％， which were significantly lower than in control group （48.7％ and 52.7％）， with statistical significance （P＜0.05）； after intervention， the circumference of lower limb， blood rheology indexes and the levels of inflammatory factors in 2 groups were decreased significantly， ?while the coagulation indicators were significantly improved； the observation group was better than the control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Danshen chuanxiongqin injection combined with flunarizine hydrochloride is effective in the prevention of BPPV and DVT in long-term bedridden patients with lower limb fractures， with low incidence of ADR.