OBJECTIVE： To explore the role of clinical pharmacists participating in anti-infective treatment for a child with complex infection. METHODS： Clinical pharmacists participated in treatment process of one child with pulmonary infection and brain abscess after a near-drowning incident， assisted physicians to adjust antibiotics therapy plan， and put several suggestions as the adjustment of anti-gram-positive and anti-gram-negtive bacterium drugs， the dosage adjustment of vancomycin， vancomycin-induced ADR and disposal， the selection of anti-Pasteurella pneumotropica drugs， the enhancement of anti-fungal infection therapy， according to pathogen characteristics， treatment effect and ADR. RESULTS： Physicians partly adopted the advice of clinical pharmacists，  the child’s pulmonary and brain infection were controlled effectively and ADR disappeared after 5 times of adjusting anti-infective the rapy plan. CONCLUSIONS： Clinical pharmacists participate in the treatment process of one child with complex infection， and assist physicians to formulate safe and effective anti-infective plan according to the results of etiological examination； dispose ADR timely and carry out efficacy evaluation of antibiotics and pharmaceutical care， that can give positive effects on patient treatment.