OBJECTIVE： To establish a method for the simultaneous determination of lithospermic acid and rosmarinic acid in Guanxin danshen capsule. METHODS： UPLC was performed on the column of ACQUITY UPLC-BEH C18 with mobile phase of 0.1％ formic acid-methanol solution （gradient elution） at a flow rate of 0.3 ml/min， detection wavelength was 280 nm， column temperature was 30 ℃， and the injection volume was 5 μl. RESULTS： The linear range was 0.019-0.76 mg/ml for lithospermic acid （r＝0.999 9） and 0.005-0.2 mg/ml for rosmarinic acid （r＝0.999 7）； RSDs of precision， stability and reproducibility tests were lower than 2％； recoveries were 97.34％-101.24％（RSD＝1.57％，n＝6） and 98.30％-100.39％（RSD＝0.86％，n＝6）. CONCLUSIONS： The method is simple， accurate and reproducible， and can be used for the contents determination of lithospermic acid and rosmarinic acid in Guanxin danshen capsule.