OBJECTIVE： To explore the effects of sufentanil combined with remifentanil on the hemodynamics， stress response and analgesic effect of elderly patients with abdominal surgery by general anesthesia. METHODS： 170 elderly patients with abdominal surgery by general anesthesia were randomly divided into control group and observation group， 85 cases in each group. All patients received general anesthesia. Control group induced anesthesia by 4 ng/kg remifentanil and maintained by 5 ng/kg； observation group induced anesthesia by 3 ng/kg sufentanil and 2 ng/kg remifentanil， maintained by 0.15 mg/（kg·h） remifentanil and 3 ng/kg remifentanil. Heart rate （HR） and mean arterial pressure （MAP） before anesthesia induction， immediately intubation， 1 min after intubation， abdominal entry and 1 min after extubation， norepinephrine and epinephrine levels before anesthesia induction， 1 min after intubation， 1 min after extubation， 6 and 12 h after surgery in 2 groups were observed， restlessness and alertness/sedation scores after extubation， 6，12，24 h postoperative visual analogue scede （VAS） score and the incidence of adverse reactions were compared. RESULTS： HR and MAP levels in 2 groups immediately intubation， 1 min after intubation， abdominal entry and 1 min after extubation significantly changed， HR and MAP levels in observation group 1 min after intubation， abdominal entry and 1 min after extubation were significantly lower than control group， the differences were statistically significant （P＜0.05）； norepinephrine and epinephrine levels in 2 groups 1 min after intubation， 1 min after extubation， 6 and 12 h after surgery significantly changed， and observation group was lower than control group， the differences were statistically significant （P＜0.05）； restlessness and alertness/sedation scores after extubation， 6，12，24 h VAS score in observation group were significantly lower than control group， the differences were statistically significant （P＜0.05）. There was no significant difference in the incidence of adverse reactions between 2 groups （P＞0.05）. CONCLUSIONS： Sufentanil combined with remifentanil can effectively stabilize hemodynamics of elderly patients with abdominal surgery， reduce the stress response levels and improve the postoperative analgesic effect， with good safety.