OBJECTIVE： To effectively control the quality of intravenous infusion product of antitumor drugs in PIVAS， and to guarantee the safety of clinical drug use. METHODS： According to the operation flow of intravenous infusion product， the quality control of anti-tumor drugs was conducted in PIVAS of our hospital from three aspects， i.e. before， during and after admixture. The improvement effect was compared before and after the implementation. RESULTS： Pre-admixture management was carried out through special classification management and medical order check management for antitumor drug； intra-admixture management was carried out through the management of admixture environment， solvent selection， admixture method， order for adding drug， dosage； post-admixture management was carried out through standard examination of infusion product and the management of delivery time and condition. 5 months later， the times of communication between PIVAS and clinical departments was decreased from 30 times to 10 times， and the incidence of infusion product was decreased from 0.68％ to 0.18％. CONCLUSIONS： Standard management has been conducted for operation procedure of anti-tumor drugs before， during and after admixture. The quality of intravenous infusion product of antitumor drugs can be effectively controlled to ensure the safety of clinical drug use.