OBJECTIVE： To observe clinical efficacy and safety of Mailuoning injection combined with benazepril in the treatment of chronic glomerulonephritis. METHODS： 130 patients with chronic glomerulonephritis were randomly divided into observation group and control group， with 65 cases in each group. Both groups received rountine treatment as low salt and fat diet. Control group was additionally given Benazepril tablet 10 mg， qd； observation group was additionally given Mailuoning injection 20 ml added into 5％ Sodium chloride injection 250 ml， ivgtt， qd， on the basis of control group， 20 days of drug withdrawal every 10 days. Both group received 4 months of treatment. Clinical efficacy of 2 groups were observed as well as the levels of BUN， UCr， SCr and 24 h urine protein quantitative （UPE） before and after the treatment. The incidence of ADR was compared between 2 groups. RESULTS： Total effective rate of observation group was 83.1％， which was significantly higher than 67.7％ of control group， with statistical significance （P＜0.05）. There was no statistical significance in BUN， UCr， SCr and 24 h UPE between 2 groups before treatment （P＞0.05）； those indexes of 2 groups decreased significantly after treatment， and the observation group were lower than the control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Mailuoning injection combined with benazepril is effective for chronic glomerulonephritis， and can effectively improve renal function with good safety.