OBJECTIVE： To investigate the clinical efficacy and safety of Yinxie capsule combired with Compound flumethasone ointment in the treatment of psoriasis vulgaris. METHODS： 66 patients with psoriasis vulgaris were divided into control group and observation group accordirg to random number table methed， with 33 cases in each group. Both groups were treated with Compound flumethasone ointment for external use， bid； based on it， observation groups was additionally given Yinxie capsule， 1.35 g each time， tid. A treatment course lasted for 8 weeks. Psoriasis area and severity index（PASI） score， dermatosis life qulity index（DLQI） score and serum inflammatory cytokines level were compared in 2 groups before and after treatment， and clinical efficacy and the occurrence of ADR were observed. RESULTS： After treatment， PASI and DLQI scores of 2 groups were decreased significantly compared to before treatment； the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. The effective rate of observation group（84.85％） was significantly higher than that of control group（63.64％）， with statistical significance （P＜0.05）. After treatment， serum levels of IL-8， TNF-α and VEGF in 2 groups were significantly lowered compared to before treatment； the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups（P＞0.05）. CONCLUSIONS： Yinxie capsule shows definite clinical efficacy in the treatment of psoriasis vulgaris by lowering serum levels of IL-8， TNF-α，VEGF and other serum inflammatory cytokines with good safety.