OBJECTIVE： To analyze the characteristics and rules of pediatric adverse drug reaction （ADR） in our hospital， and provide reference for clinical safe drug use. METHODS： Retrospective study was adopted to statistically analyze the ADR reports in our hospital from Mar. 2012 to Jun. 2016. RESULTS： In the 176 ADR reports， 102 were male （57.95％） and 74 were female （42.05％）； children younger than 6 years old had the highest incidence of ADR （81.26％）； intravenous administration induced 153 cases （86.93％）， the top one was antibiotics， which involving 20 antibiotics， totally 106 cases （60.23％）； skin and its appendages damage were the main manifestations， totally 127 cases （50.60％）. CONCLUSIONS： Pediatric ADR monitoring should be strengthened， dinical rational drug use should be promoted by cooperation in many ways to reduce and prevent the inciderle of pediatric ADR.