OBJECTIVE： To observe clinical efficacy and safety of Ebastine tablet combined with Chushi zhiyang ointment in the treatment of hand keratinizing chapped eczema. METHODS： 135 cases of hand keratinizing chapped eczema were divided into control group A （45 cases）， control group B （43 cases） and treatment group （47 cases） according to treatment regimen. Control group A was orally given Ebastine tablet， 10 mg each time， qd； control group B was given Chushi zhiyang ointment alone， twice a day， morning and evening， applying thin layer of ointment on the affected area； treatment group was given same dose of Ebastine tablet orally and applied Chushi zhiyang ointment on the affected area. 3 groups received treatment for consecutive 4 weeks. Clinical efficacies of 3 groups were observed as well as the scores of pruritus， skin lesion area， keratinization， rhagades and VAS before and after treatment. The occurrence of ADR was compared among 3 groups. RESULTS： The total effective rate of treatment group was 68.09％， which was significantly higher than that of group A （42.22％） and control group B （16.28％）， with statistical significance （P＜0.05）. There was no statistical significance in the scores of pruritus， skin lesion area， keratinization， rhagades and VAS among 3 groups before treatment （P＞0.05）. After treatment， above scores of 3 groups decreased significantly， and those of treatment group were significantly lower than those of control group A and B， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR among 3 groups （P＞0.05）. CONCLUSIONS： Ebastine tablet combined with Chushi zhiyang ointment is effective for hand keratinizing chapped eczema， and can significantly improve the skin of patients with good safety.