OBJECTIVE： To improve the level of rational drug use， and to reduce the workload of clinical pharmacists. METHODS： Established “Intelligent Management and Solution for Clinical Rational Drug Use” of our hospital was introduced， including post-prescription review （all prescriptions review） system，  self-maintenance system for rational drug use knowledge base， pre-prescription review （rational drug use real-time review） early warning system. The effects of intelligent system were evaluated. RESULTS & CONCLUSIONS： After the application of the system， the following aspects could be achieved， including “all prescriptions review”， “multi-prescriptions/longitudinal review”， system knowledge base real-time update and autonomous definition of review rules， effective communication and intervention between physicians and pharmacists before printing prescription by Yaozhidao instant messaging system. Through related trial evaluation， the proportion of false positive prescriptions decreased by 17.65％ after 4 months of the application of the system； drug consultation prescriptions review average score of outpatient pharmacists increased from 81 to 94.85； the time of prescription review decreased by 4.72-5.46 times. Through mandatory interception of unqualified prescriptions， severe warning， timely prompt and pharmacists’ intervention， the rate of unqualified prescriptions pre-reviewed by the system in respiration department decreased from 32％ in Jan. 2015 and 21％ in May to 4.62％ in Dec. So， the application of the system promotes rational drug use in outpatient department， reduces the workload of pharmacists and ensures the safety of drug use comprehensively.