OBJECTIVE： To investigate the distribution and drug resistance of Acinetobacter baumannii  in our hospital， and provide reference for rational use of antibiotics. METHODS： Clinical specimen of inpatients in our hospital from Jan. 2012 to Dec. 2015 was collected， the identification of strains and drug sensitivity test were performed by the VITEK-2 microorganism analyzer； use rate of antibiotics and detection of multidrug-resistant and pandrug-resistant A. baumannii  for inpatients in our hospital were analyzed， and their correlation was detected by Pearson correlation analysis. RESULTS： Totally 2 468 strains of A. baumannii  were isolated in our hospital during 2012-2015， mainly derived from sputum samples （88.2％）， distributed in respiratory medicine department （47.0％） and ICU （13.1％）； A. baumannii  showed totally high drug resistance to common antibiotics， and only sensitive to tigecycline. Totally 386 （79.3％）， 434 （61.6％）， 358 （53.4％） and 291 （48.0％） strains multidrug-resistant A. baumannii were detected every year in our hospital； and pandrug-resistant A. baumannii  were 336 （69.0％）， 385 （54.7％）， 331 （49.3％） and 256 （42.2％） strains， respectively. There was a positive correlation between the percentage of multidrug-resistant and pandrug-resistant A. baumannii in total strains and use rate of antibiotics （r＝0.987、0.981，P＜0.05）. CONCLUSIONS： A. baumannii has emerged as an important pathogen in hospital acquired infections， which mainly caused respiratory system infection； the drug resistance situation is not optimistic， tigecycline can be used as one of the best choice for treatment of A. baumannii  infections； our hospital should continue to control the use of antibiotics to decrease the emerging of drug resistance strains.