OBJECTIVE： To evaluate the effect of comprehensive intervention management mode on the use of proton pump inhibitors （PPIs） injection in oncology department of hospital. METHODS： Simple random sampling method was conducted to collect 1 457 discharged medical records used PPIs injection in oncology department of our hospital from Jan. 2012 to Dec. 2013 （before intervention） and 793 records from Jan. to Dec. 2014 （after intervention）. The utilization of PPIs injection before and after administrative intervention， technical intervention and information management was compared. RESULTS： After comprehensive intervention， the utilization rate of PPIs injection in oncology department of our hospital decreased from 62.59％ （before intervention） to 60.70％， without significant difference （P＞0.05）. There were significant differences in the proportion of PPIs injection’s consumption amount in total medical costs and per capita consumption amount before and after intervention （P＜0.05）； the utilization rate of Lansoprazole for injection increased from 19.70％ （before intervention） to 34.68％， and the Omeprazole for injection decreased from 34.45％ （before intervention） to 25.60％， with significant differences （P＜0.05）， while there were no significant differences in the utilization rate of Pantoprazole for injection and Esomeprazole for injection （P＞0.05）. The proportion of irrational use of PPIs injection decreased from 73.99％ （before intervention） to 55.86％， among which， the proportions of no indications of medication， repeated administration and too long duration decreased from 40.01％， 17.09％ and 26.90％ （before intervention） to 32.41％， 9.08％ and 18.03％， with significant differences （P＜0.05）， while there was no significant difference in the proportion of inappropriate dose selection before and after intervention （P＞0.05）. CONCLUSIONS： Comprehensive intervention management mode can improve the clinical utilization of PPIs injection in oncology department of our hospital to some extent， but the irrational use of PPIs injection in our hospital is still not optimistic， which needs further improve intervention to promote its clinical rational use.