OBJECTIVE： To standardize hospital purchasing management for medicinal material. METHODS： The separation of the four powers， including plan， purchase， supply， and payment， was practiced on the basis of centralized purchasing medicinal material in our hospital. SWOT method was used to analyze the strengths， weaknesses， opportunities and threats of the model； improvement measures were formulated； finally the effects of the model were evaluated. RESULTS： This model played an active role in the professional advantage of purchasing management， made up for the lack of management system and manpower shortage disadvantage； adapted to policies to seize the opportunities for improvement， reduced the threat of standard deletion and purchasing cost， and promoted reasonable consumption of medicinal materials. And then the purchasing cost of our hospital was reduced after system procedure improvement， fine management of medicinal material and professional level improvement， medicine ratio fell from 42％ in 2010 to 37％ in 2014； logistics support became stable and standard， and the level of medicinal material supply was improved. CONCLUSIONS： The purchasing model for medicinal material under separation of the four powers provides the reference for the correct course of the standardized， normalized and modernized hospital purchasing management.