OBJECTIVE： To establish a method for the simultaneous determination of chlorogenic acid， vitexin glucoside， vitexin rhamnoside， vitexin， rutin and hyperoside in Crataegus pinnatifida. METHODS： With reference peak of vitexin glucoside， HPLC was conducted to calculate the relative correction factor （RCF） of chlorogenic acid， vitexin glucoside， vitexin rhamnoside， vitexin， rutin and hyperoside， then the contents of above-mentioned 5 components in C. pinnatifida were calculated. The column was Agilent ZORBAX SB C18 with mobile phase of 0.1％ formic acid-acetonitrile-tetrahydrofuran （gradient elution） at a flow rate of 1.0 ml/min， the detection wavelength was 350 nm， column temperature was 30 ℃， and the injection volume was 10 μl. RESULTS：The linear range was 12.50-400.0 μg for chlorogenic acid （r＝0.999 8）， 25.00-800.0 μg for vitexin glucoside（r＝0.999 9）， 31.25-1 000.0 μg for vitexin rhamnoside （r＝0.999 9）， 6.470-260.0 μg for vitexin （r＝0.999 9）， 2.50-80.0 μg for rutin （r＝0.999 8） and 9.375-300.0 μg for hyperoside （r＝0.999 9）； RSDs of precision， stability and reproducibility tests were lower than 2.0％； recoveries were 99.2％-103.9％ （RSD＝1.6％，n＝6），97.9％-100.8％ （RSD＝1.2％，n＝6）， 99.2％-100.8％ （RSD＝0.5％，n＝6）， 97.3％-101.3％ （RSD＝1.5％，n＝6）， 98.0％-103.0％（RSD＝1.9％，n＝6） and 95.5％-101.5％（RSD＝2.2％，n＝6）. RCFs of vitexin glucoside with chlorogenic acid， vitexin rhamnoside， vitexin， rutin and hyperoside were 1.119， 1.009， 0.706， 1.063 and 0.830， respectively. CONCLUSIONS： The method is simple with good precision， stability and reproducibility， and it can be sued for the simultaneous determination of 6 components in C. pinnatifida.