OBJECTIVE： To investigate the effects of Shenmai injection combined with sodium ferulate on infarct size and related indicators of patients with acute myocardial infarction. METHODS： 110 patients with acute myocardial infarction were randomly divided into control group（55 patients） and observation group（55 patients）. Patients in the control group received oxygen inhalation， coronary expansion by nitrates， water and electrolyte regulation and acid-base balance regulation， thrombolytic fibrinolytic agent utilization， sedation and analgesia by analgesics and other conventional treatments. Meanwhile，50 ml Shenmai injection was given to the control group， dissolved in 200 ml 5％ Glucose injection， intravenously， twice a day； observation group was additionally given 0.2 g Sodium ferulate for injection， dissolved in 200 ml 5％ Glucose injection， intravenously， twice a day. The treatment course for both groups was 14 d. Clinical efficacy in 2 groups was observed， myocardial infarction size before and after treatment was recorded， hemorheology indexes （whole blood viscosity， fibrinogen and erythrocyte aggregation index）， catdiac enzymes index homocysteine （Hcy）， and growth arrest-specific gene product 6 （Gas6） before and after treatment together with the incidence of adverse reactions were detected. RESULTS： The total effective rate in observation group was significantly higher than it in control group. The difference was statistically significant （P＜0.05）； before treatment， there were no statistically significant differences in the myocardial infarction size， hole blood viscosity， fibrinogen， erythrocyte aggregation index， and blood level of Hcy and Gas6 （P＞0.05）. After treatment， the myocardial infarct size in 2 groups was reduced， hole blood viscosity， fibrinogen and erythrocyte aggregation indexes were reduced， and these in observation group were lower than in control group； in the 8 day during the treatment， serum level of Hcy in observation group was reduced； in the 15 day， blood level of Hcy and Gas6 in observation groups was reduced， serum level of Hcy in control group was reduced， and these in observation group was lower than in control group. The differences were statistically （P＜0.05）. And there were no obvious adverse reactions during treatment. CONCLUSIONS： Based on conventional treatment， Shenmai injection combined with sodium ferulate shows significant efficacy in the treatment of acute myocardial infarction， and can reduce blood level of Hcy and Gas6， improve hemorheology indexes and narrow the myocardial infarct size.