OBJECTIVE： To compare the improvement effects of Morinda officinalis and its processed products on rats with spleen-kidney Yang deficiency. METHODS： 80 rats were randomly divided into normal group （normal saline）， model group （normal saline）， excipients group （succus liquiritiae， 0.063 g/kg）， Quanlu pill group （positive drug， 1.89 g/kg）， M. officinalis group， M. officinalis without wood， M. officinalis processed by salt and M. officinalis processed by licorice-juice groups [1.05 g （crude drug）/kg]. Those groups were given Rheum palmatum water solution intragastrically and hydrocortisone intramuscularly to induce spleen-kidney Yang deficiency model， and given relevant medicine intragastrically once a day for consecutive 15 d. The levels of testosterone（T）， estradiol（E2）， cAMP， cGMP， triiodothyronine （T3）， thyroxine （T4）， adrenal cortex hormone（ACTH） in the serum were measured， and E2/T and cAMP/cGMP were calculated. RESULTS： Compared with normal group， the serum level of T， T3， T4 and cGMP decreased in model group， while the levels of E2， cAMP and ACTH， E2/T and cAMP/cGMP increased （P＜0.05 or P＜0.01）. Compared with model group， serum level of T increased in treatment groups， while serum levels of E2， cAMP， ACTH and cAMP/cGMP decreased （P＜0.05 or P＜0.01）； serum level of T was highest and E2/T was the lowest in M. officinalis processed by salt group； serum level of E2， cAMP， ACTH and cAMP/cGMP were the lowest in M. officinalis processed by licorice-juice group； serum level of cGMP increased in M. officinalis group and M. officinalis processed by licorice-juice group （P＜0.01）； serum levels of T3 in M. officinalis， M. officinalis processed by salt and M. officinalis processed by licorice-juice groups， and T4 increased in all treatment groups （P＜0.05 or P＜0.01）， especially in M. officinalis processed by licorice-juice group. CONCLUSIONS： M. officinalis processed by licorice-juice is better in improving spleen-kidney Yang deficiency， compared to M. officinalis and its other processed products.