OBJECTIVE： To analyze and evaluate ADR-induced death cases in children in order to find drug use risk and provide reference drug use in children. METHODS： All ADR-induced death cases were selected from Henan ADR Information Monitoring System during 2004-2013， and then the risk of drug use in children was analyzed in terms of drug package inserts， literature report， ADR information bulletin， etc. RESULTS： Of 13 death cases， suspected drugs were all injection via intravenous administration and the large part of them were cephalosperin injection-induced ADR reports， accouating for 37.50％； only 5 cases were reported immediately， accounting for 38.46％. The longest prolonged reporting time was 29 d. Irrational drug use existed at different levels， including antibiotics abuse， medication error， overdose use， violation of contraindication and other risk factors. CONCLUSIONS： Some measures should be taken to standardize rational drug use in children， such as formulating pediatric medication guideline， reducing drug combination， using drugs in accordance with package inserts strictly it is necessary to submit complete and accurate ADR report in time.