OBJECTIVE： To investigate the effects of Maiqi jiangtang pill combined with insulin on related indicators in maternal gestational diabetes. METHODS： 135 GDM women were randomly divided into control group （69 cases） and observation group （66 cases）. Control group was given diet controlling and exercise therapy， Novolin R insulin biosynthesis and protamine synthetic human insulin were injected before meals and bedtime from 4-6 units with the ratio of 4 ∶ 2 ∶ 3 ∶ 1， and decided whether to adjust the insulin dose based on the blood glucose monitoring results （increase or decrease 2-4 units each times）； observation group was additionally given 6 g Maiqi jiangtang pill， 4 times a day. The treatment course for both groups was 15 d. Fasting plasma glucose （FPG）， 2 h postprandial glucose （2 h PG）， glycated hemoglobin （HbA1c）， body mass index （BMI）， maternal pregnancy outcomes （preeclampsia， preterm labor， puerperal infection， postpartum hemorrhage， neonatal asphyxia， low-weight children and nocturnal hypoglycemia） and incidence of adverse reactions in 2 groups were observed. RESULTS： FPG， 2 h PG， HbA1c， BMI， preeclampsia， preterm labor， low-weight children， neonatal asphyxia and nocturnal hypoglycemia in observation group were significantly lower than control group， the differences were statistically significant （P＜0.05）； there were no significant differences in the puerperal infection and postpartum hemorrhage between 2 groups （P＞0.05）. And there were obvious adverse reactions between 2 groups during treatment. CONCLUSIONS： Maiqi jiangtang pill combined with insulin can effectively reduce the blood glucose of GDM women， with good safety.