OBJECTIVE： To improve high-alert medication management in our hospital. METHODS： According to assessment criteria of JCI， referring to the problems of high-alert medication management in our hospital， PDCA （plan， do， check， action） cycle method， reverse fishbone diagram and other methods were adopted to formulate and implement relevant countermeasures. Compliance rate of 29 departments was evaluated within 12 months after the implementation of countermeasures. RESULTS： Relevant emergency measures were formulated for 2 negative factors by reverse fishbone diagram； whole-course and orderly quality control of high-alert medication was conducted through establishing high-alert medication management institutions， formulating high-alert medication management system and quality measurement criteria， strengthening staff training and education， improving hospital information system， etc. The compliance rate of departments increased from 53％ in Jan. to 100％ in Jun. （P＜0.05）， and kept stable until Dec. CONCLUSIONS： PDCA cycle improves the systemization and standardization of high-alert medication management and multiple department cooperation， and contributes to the safety of drug use.