OBJECTIVE： To establish EQ-5D value sets for the whole southwest population， local urban and country people of southwest area of China， in order to provide an effective method to calculate utility values when conducting cost-utility analysis using EQ-5D. METHODS： Taking Guizhou province as example， 240 urban and country population aged over 16 years were selected as respondents. Utility values for a subset of 97 health states defined by the EQ-5D descriptive system were directly elicited by applying TTO technique. Econometric model was establish on the basis of individual and mean value. The predictive ability， adjusted R2， mean absolute error， etc. were used to choose the best model. RESULUTS： A total of 481 questionnaires were sent out and 467 valid questionnaires were collected with the effective rate of 97.09％. EQ-5D value sets for the whole population， local urban and country people of Guizhou province could be obtained by N3 model and the main effects at the average level. The southwest population from urban tended to give lower values to the moderate and severe heath states compared them from country. The country people gave greater weight to mobility， usual activities and self-care， while the urban people gave greater weight to anxiety/depression. CONCLUSIONS： The study can provide reference for medical resource allocation and decision-making in southwest of China.