OBJECTIVE： To strengthen the supervision of drug stocktaking， and to improve drug management. METHODS： The data of drug stocktaking were extracted from our hospital from 2011 to 2014， and was analyzed in respects of accounts coincidence rate， drug profit and loss account rate， the entry and exit account between departments and original record， etc. A series of supervision strategies were established， and the data of drug stocktaking was analyzed during Jan.-Jun. in 2015 statistically to evaluated supervision effects. RESULTS： The supervision of drug stocktaking was strengthened through limiting the right of drug profit and loss on stocktaking， strengthening original stocktaking record management， establishing Key Drug List， setting up drug stocktaking supervision institutions， etc. During Jan.-Jun. in 2015， there was obvious improvement in the drug supervision skills， in terms of account coincidence rate， profit and loss account， material safety， cash flow rate， staff responsibility and stocktaking duration， etc. More specially， the accounts coincidence rate had rose from about 82.8％ to more than 95％； both the key drug accounts coincidence rate and the entry and exit account between departments coincidence rate had reached to 100％； the profit and loss account rate had reduced from about 7.6％ to less than 0.3％； the stocktaking time had reduced from 10 h to 3 h. CONCLUSIONS： Strengthening drug stocktaking supervision can not only improve the stocktaking efficiency and quality markedly， but also contributes to the development of other pharmacy work in hospital.