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更新时间：2023-03-01

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- China Pharmacy Vol. 27, Issue 8, (2016)
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[J]. China Pharmacy 27(8).(2016)
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[J]. China Pharmacy 27(8).(2016) DOI：

摘要

目的：为临床合理使用新型口服抗凝药（NOACs）治疗非瓣膜性房颤（NVAF）提供参考。方法：查阅近年来国内外相关文献，对NOACs在治疗NVAF中的研究进行归纳和分析。结果：凝血酶抑制剂达比加群酯和Ⅹa因子抑制剂利伐沙班、阿哌沙班、依度沙班和贝曲西班等NOACs相较于华法林在NVAF患者中，能显著降低卒中、颅内出血及死亡的发生率。NOACs服用方便、无需检测凝血指标、无需频繁调整剂量，在最新的房颤指南中得到推荐，但临床研究有限，价格昂贵，缺乏有效的拮抗药。结论：NOACs在治疗NVAF中有可观的临床发展前景。

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新型口服抗凝药非瓣膜性房颤华法林药物经济学

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Related Institution

Dept. of Pharmacy， Nanjing Drum Tower Hospital

School of Basic Medicine and Clinical Pharmacy， China Pharmaceutical University

Dept. of Cardiology， Nanjing Drum Tower Hospital

Dept. of Pharmacy， the Affiliated Hospital of North Medical College， Sichuan Nanchong

School of Pharmaceutical Sciences， Peking University

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