OBJECTIVE：To observe the efficacy and safety of Reduced glutathione for injection combined with Silibinin capsule in the treatment of cirrhosis. METHODS： 140 cirrhosis patients were randomly divided into observation group and control group. All patients were required smoking prohibition and given high protein， high vitamin， low-fat diet， taking the liver protecting and lipid-lowering drugs， and other conventional treatment. Based on it， control group was given 1.8 g Reduced glutathione for injection， adding into 250 ml 10％ Glucose injection by intravenous infusion， once a day； observation group was additionally given 105 mg Silibinin capsule， orally， 3 times a day. The treatment course for both groups was 5 weeks. Clinical efficacy， liver functions （ALT，AST，GGT）， serum fibrosis markers （LN，HA，PC-Ⅲ） before and after treatment and incidence of adverse reactions in 2 groups were observed. RESULTS： The total effective rate in observation group was significantly higher than control group， the difference was statistically significant（P＜0.05）. after treatment， the liver functions and serum fibrosis markers in 2 groups were significantly lower than before， and observation group was lower than control group， the differences were statistically significant（P＜0.05）， and there was no significant difference in the incidence of adverse reactions（P＞0.05）. CONCLUSIONS： Based on the conventional treatment， the efficacy of Reduced glutathione for injection combined with Silibinin capsule is significantly superior to Reduced glutathione for injection alone in the treatment of cirrhosis，with similar safety.