OBJECTIVE： To investigate the safety of Ceftriaxone sodium injection and Levofloxacin injection through obtaining relevant data of the incidence of ADR. METHODS： By using prospective active monitoring mode， all patients that took Ceftriaxone sodium injection and Levofloxacin injection in the inpatient department of 4 pilot hospitals during Mar.-Sept. 2013 were monitored， recorded and analyzed statistically in respects of gender， age， medication duration， dosage form， involved organs and clinical manifestations， etc. Then calculate the incidence of ADR. RESULTS： Total incidence of ADR induced by Ceftriaxone sodium injection was 0.23％（3/1 318）， and that of Levofloxacin injection was 0.82％（7/851）. The incidence of ADR in female patients was higher than in male patients after given Levofloxacin injection， there was statistical significance （P＜0.05）. There was no statistical significance in the occurance of ADR and gender， timing， preparation et al. Lesion of skin and its appendants was main ADR manifestations， accounting for 53.33％. All patients were cured or recovered. CONCLUSIONS： Active monitoring mode is benefit to calculate the incidence of ADR. Clinicians should pay attation to the occurrence of ADR.