OBJECTIVE：To explore the effects of omeprazole combined with Huxue huayu tongluo formula on the efficacy and relevant indexes of diabetic gastroparesis gastric motility disorder. METHODS：92 patients with diabetic gastroparesis gastric motility disorder were randomly divided into observation group and control group. All patients were given diabetes dietary guidance and exercise guidance， and patients with combined metabolic disorders and hypertension were given lipid lowering， antihypertensive and other conventional treatment； based on it， control group was orally given 20 mg Omeprazole enteric-coated capsule， once a day； observation group was additionally given 300 ml Huxue huayu tongluo formula， 150 ml once， twice a day. The treatment course for both groups was 14 d. Clinical efficacy， fasting blood glucose， glycated hemoglobin， whole blood viscosity level， motilin， gastrin， half gastric emptying time （GET1/2） before and after treatment， and the incidence of adverse reactions in 2 groups were observed. RESULTS：The total effective rate in observation group was significantly higher than control group， the difference was statistically significant（P＜0.05）； before treatment， there were no significant differences in the fasting blood glucose， glycated hemoglobin， whole blood viscosity level， motilin， gastrin and GET1/2（P＞0.05）； after treatment， fasting blood glucose， glycated hemoglobin， whole blood viscosity level， motilin， gastrin and GET1/2 in 2 groups were significantly lower than before， and observation group was lower than control group， the differences were statistically significant（P＜0.05）； and there were no adverse reactions during treatment. CONCLUSIONS： Based on the conventional treatment， the efficacy of omeprazole combined with Huxue huayu tongluo formula is superior to omeprazole alone for diabetic gastroparesis gastric motility disorder， it can significantly reduce blood glucose and improve hemodynamics， with similar safety.