OBJECTIVE： To observe the effects and safety of ultrasound guided paravertebral nerve block on hemodynamics， analgesic effect and inflammatory index in patients underwent pulmonary lobectomy. METHODS： 72 patients underwent selective pulmonary lobectomy in our hospital were randomly divided into observation group and control group， with 36 cases in each group. All patients were given endotracheal intubation general anesthesia and maintain BIS 40-60. Control group was given sulfentanyl 0.1 μg/kg 10 min for intravenous analgesia pump before operation， and sulfentanyl 1.0 μg/ml， at 2 ml/h， 2.5 ml/time for self-control， self-control interval of 15 min. Observation group underwent ultrasound guided paravertebral nerve block before operation， and given 0.2％ ropivacaine 15 ml via paravertebral block indwelling catheter for analgesia pump， analgesia regimen： 0.2％ ropivacaine， at 2 ml/h， 2.5 ml/time for self-control， self-control interval of 15 min. Hemodynamic index， inflammatory index， VAS and the incidence of ADR were observed in 2 groups before and after operation. RESULTS： The HR of observation group was significantly lower than that of control group 30 min after extubation， 6 and 12 h after operation， with statistical significance （P＜0.05）. There was no statistical significance in HR 24 and 48 h after operation and MAP 12， 24 and 48 h after operation， without statistical significance （P＞0.05）. VAS of observation group was significantly lower than that of control group 30 min after extubation， 6， 12 and 24 h after operation， with statistical significance （P＜0.05）. There was no statistical significance in VAS between 2 groups 48 h after operation （P＞0.05）. Plasma IL-6 and TNF-α level of observation group were significantly lower than those of control group， but plasma IL-10 level was significantly higher than control group 30 min after extubation， 6， 12 and 24 h after operation， with statistical significance （P＜0.05）. The incidence of ADR was 11.1％ in observation group， which was significantly lower than 33.3％ of control group， with statistical significance （P＜0.05）. CONCLUSIONS： Ultrasound guided paravertebral nerve block shows good postoperative analgesia effect in patients underwent pulmonary lobectomy， keep hemodynamics stable and effectively reduce postoperative inflammatory reaction with low incidence of ADR.