OBJECTIVE： To provide reference for imipenem-resistant Pseudomonas aeruginosa infection control. METHODS： 114 patients infected with imipenem-resistant P. aeruginosa were selected from 3 tertiary hospitals in Zhoushan during Feb. 2013 to Feb. 2014. 114 strains of P. aeruginosa were isolated from clinical specimens， and drug resistance characteristics and carbapenemase-producing gene diversity were analyzed. 101 inpatients with imipenem-resistant P. aeruginosa infection were included in control group； univariate and multivariate Logistic regression analysis were adopted to explore the risk factors of imipenem-resistant P. aeruginosa infection. RESULTS： 114 strains were sensitive to polymyxin B， and had different levels of resistance to other 9 kinds of antibiotics. Carbapenemase-producing gene were mainly IMP and VIM type gene. Long-term hospitalization， mechanical ventilation， used imipenem and early combined use of antibiotics were risk factors of imipenem-resistant P. aeruginosa infection. CONCLUSIONS： In Zhoushan area， imipenem-resistant P. aeruginosa shows serious drug resistance. To avoid long-term hospitalization and early combined use of antibiotics can reduce imipenem-resistant P. aeruginosa infection.