OBJECTIVE： To provide reference for improving the cognition of medical staff for adverse drug reactions （ADR）. METHODS： A questionnaire survey was conducted on the spot among the physicians， nurses and pharmacists with different professional titles in our hospital to investigate their cognition about ADR concept， their judgment for ADR and ADR reporting， and the results were analyzed by statistical methods. RESULTS： Totally 452 questionnaires were sent out， and 439 were effectively received， with effective rate of 97.12％. In terms of correct cognition rate about ADR basic concept and the main reasons， the surveyed pharmacists were higher than physicians and nurses， the senior professional titles of surveyed pharmacists were higher than the intermediate and junior， the pharmacists with senior professional titles were the highest and the junior were the lowest， the differences were statistically significant （P＜0.05）； in terms of the proportion of certain for ADR judgment， the surveyed nurses were lower than pharmacists and physicians， the surveyed physicians with senior and intermediate professional titles were higher the junior，the surveyed nurses with intermediate titles were higher than the junior， the surveyed pharmacists with senior professional titles were higher than the intermediate and the junior， the differences were statistically significant （P＜0.05）； in terms of cognition about ADR reporting， the surveyed pharmacists were the highest and the nurses were the lowest， the differences were statistically significant （P＜0.05）， while in terms of the proportion of knowing ADR reporting timing limit， reporting procedures and departments， the surveyed pharmacists and physicians with junior professional titles were lower than the senior and intermediate， the differences were statistically significant （P＜0.05）； in terms of reasons for missed ADR reporting， the proportion of consideration of the risk of causing medical disputes for doctors of the surveyed physicians was higher than pharmacists and nurses， while the surveyed nurses showed higher proportion for doing not understand reporting procedures， doing not reporting， thinking ADR reporting was dispensable and uncertain for ADR identification， the differences were statistically significant （P＜0.05）. CONCLUSIONS： Medical staff with different professional titles and occupations have different cognition about ADR basic concept， judgment and reporting， the pharmacist are relatively good， followed by the physician and nurse， especially the nurse， and the medical staff with junior professional titles are relatively poor. It is necessary to strengthen ADR education and training for them， play professional advantages from the pharmacist and optimize ADR reporting procedures to improve the reporting rate and quality of ADR.