OBJECTIVE： To observe the effects of total organic acid of Thladiantha dubia fruit （TOATF） on coagulation time and hemorheology of rats with cold coagulation and blood stasis. METHODS： 60 rats were randomly divided in normal control group （water）， model control group （water）， aspirin group （positive drug， 50 mg/kg） and TOATF low-dose， medium-dose and high-dose groups （50， 100， 200 mg/kg） with 10 rats in each group. Except for normal control group， cold coagulation and blood stasis model was induced by 4 ℃ water bath and subcutaneous injection of adrenaline hydrochloride， and then given correspondence medicine intragastrically， once a day， for consecutive 14 d. 24 h after last administration， blood samples were collected from aorta abdominalis. The coagulating time （CT）， erythrocrit （HCT）， plasma viscosity （PV）， prothrombin time （PT）， thrombin time （TT）， activated partial thromboplastin time （APTT）， platelet aggregation rate （PAR） and whole blood low-shear， middle-shear and high-shear viscosity were measured and blood sedimentation equation K value was calculated. RESULTS： Compared with normal control group， CT， PT， TT and APTT of model control group were shortened， and HCT， PV， blood sedimentation equation K value， PAR and whole blood low-shear， middle-shear and high-shear viscosity increased （P＜0.05 or P＜0.01）. Compared with model control group， CT， PT and APTT prolonged in aspirin group and TOATF medium-dose and high-dose groups， and PAR decreased； PT of treatment groups prolonged， while HCT， PV， blood sedimentation equation K value and whole blood low-shear and middle-shear viscosity decreased （P＜0.05 or P＜0.01）. CONCLUSIONS： TOATF has obvious improvement effects on anticoagulation and hemorheology in rats with cold coagulation and blood stasis.