OBJECTIVE： To prepare Geinstein （GEN） solid dispersion， and improve the dissolution rate of GEN in vitro. METHODS： Using PVP K30， PEG6000， and PEG4000 as carriers， GEN solid dispersion was prepared by solvent melting method， and its dissolution in vitro was investigated. The structure of the solid dispersion was characterized by FTIR and DSC. RESULTS： GEN solid dispersion prepared with PEG4000 as carrier was better than those with other carriers in dissolution， and drug-carrier ratio （1 ∶ 5） was the best. The results of DSC and FTIR showed that GEN in solid dispersion took amorphous form. CONCLUSIONS： GEN solid dispersion is prepared successfully and significantly improve the dissolution of GEN in vitro.