OBJECTIVE： To discuss the effect of performance management in medication consultation service in hospital， and to improve the service quality in medication consultation center. METHODS： The performance management mode of medication consultation center was implemented in our hospital through formulating consultation pharmacist performance evaluation content and accounting rules from four dimensions of business skills， cultural literacy， work attitude， workload， conducting daily evaluation and check， developing training， setting development plan， etc. The effects of the mode were evaluated. RESULTS： In performance evaluation， business skills， cultural literacy， work attitude and workload took up 20， 15， 15 and 50 points， respectively； they were subdivided into 16 specific items and extra point items. After the implementation of above performance management， average weekly clients increased from 104 persons to 247 persons （increasing by 138％）； the proportion of patient medication education mainly provided by clinical pharmacists increased from 18.30％ to 46.34％ （increasing by 153％）； the complex and professional problems of medication consultation such as drug interaction rose from 0.96％ to 5.28％； the problem of drug usage and dosage increased from 6.73％ to 23.17％. The performance management mode not only improved the service consciousness and the enthusiasm of consultation pharmacists， but also improved the level of pharmaceutical care. CONCLUSIONS： Reasonable and effective performance management mode can promote the service quality and ability of medication consultation center， and play more important role in hospital pharmaceutical care.