OBJECTIVE： To explore the mode and role of clinical pharmacists providing pharmaceutical care for icotinib-induced liver damage in patient with hepatitis B virus. METHODS： Clinical pharmacists participated in pharmaceutical care for icotinib-induced liver damage in a patient with hepatitis B virus， analyzed the cause of liver damage and suggested to stop taking Icotinib hydrochloride tablet； Bicyclol tablet 25 mg，po，tid+Sodium glucuronate injection 0.266 g，ivgtt，qd+Polyene phosphatidylcholine injection 10 ml，ivgtt，qd for protecting liver； avoid the increase of liver burden induced by reduced glutathione； stopped taking Sodium glucuronate injection and Polyene phosphatidylcholine injection and continued to take icotinib 125 mg， po， tid after liver function recovered； stopped taking Icotinib hydrochloride tablet and continued to take Bicyclol tablet for 6 months after progression disease. RESULTS： Physician adopted the suggestions of clinical pharmacists， adopted above treatment plan for 36 d， the patient stopped taking Icotinib hydrochloride tablet and liver function index recovered to normal after 42 days. CONCLUSIONS： Clinical pharmacists provide individualized medication guideline and guarantee the safe， rational and effective use of drugs.