OBJECTIVE： To observe clinical efficacy and safety of triptorelin acetate in the treatment of endometriosis after laparoscopy. METHODS： 196 cases of endometriosis were randomly divided into experimental group and control group with 98 cases in each group according to admission sequence. Both groups received laparoscopic surgery. After surgery， experimental group was given triptorelin acetate by intramuscular injection， 3.75 mg/time， every 4 weeks； control group was given gestrinone orally， 2.5 mg/time， twice a week， for 5 months. The ovulation， menstrual recovery and the occurrence of ADR were observed in 2 groups. The endometriosis relapse of 2 groups were followed up for 1 year and observed. RESULTS： After treatment， the ovulation recovery time and menstrual recovery time of experimental group were all shorter than those of control group， with statistical significance （P＜0.05）. The incidence of ADR in experimental group （17.34％） was significantly lower than in control group （35.71％）， with statistical significance （P＜0.05）. During follow-up period， the relapse rate of experimental group （7.14％） was significantly lower than that of control group （18.37％）， with statistical significance （P＜0.05）. CONCLUSIONS： After laparoscopic surgery， triptorelin acetate can significantly improve therapeutic efficacy of endometriosis， reduce the occurrence of ADR.