OBJECTIVE：To compare and analyze the contents of inorganic elements in 15 kinds of Paeonol saffuruticosa from different origins，and to lay the fowndation for the discrimination of its genuine regional drug. METHODS：ICP-MS and ICP-OES were conducted to determine the contents of inorganic elements in 15 kinds of P. saffuruticosa. ICP-MS determination conditions： the powder was 1 200 W， atomizer pressure was 1.6 bar， molecular pump motor current was 2 A， molecular pump speed was 1 000 Hz， bake box tuning parameters were Load 59 and Tune 190； ICP-OES determination conditions： the powder was 1 300 W， plasma gas flow rate was 15 L/min， auxiliary cooling gas flow was 0.2 L/min， atomizer flow rate was 0.8 L/min， reading time （automatic） was 1-5 s， and the injection volume was 1.5 ml/min. SPSS 19.0 software was conducted for the cluster analysis of 15 batches of samples； SIMCA-P 11.0 software was combined with principal component analysis （PCA） and partial least squares discriminant analysis （PLS-DA） to analyze the main elements in 15 batches of samples. RESULTS： Cluster analysis showed specific areas （Tongling） and non-specific area may be better and divided into two types； PCA can cluster the medicines from different origins into different groups； PLS-DA shows the main elements in samples were lithium， zinc， lead， iron and potassium. CONCLUSIONS： The contents of inorganic elements in P. saffuruticosa genuine regional drug and non-genuine regional drug one show certain differences with the types.